Assay Detail
Functional
CHEMBL691388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HIV-1 AZTres.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338047 | — | — | 1 | 9.70 |
| CHEMBL128931 | — | — | 1 | 7.60 |
| CHEMBL338936 | — | — | 1 | 7.15 |
| CHEMBL339511 | — | — | 1 | 7.12 |
| CHEMBL128812 | — | — | 1 | 6.38 |
| CHEMBL129144 | — | — | 1 | 6.36 |
| CHEMBL57733 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338047 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL128931 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL338936 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL339511 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL128812 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL129144 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL57733 | — | IC50 | = | 4350.0 | nM | 5.36 |