Assay Detail
Functional
CHEMBL691389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HIV-1 Bal/Mono
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.01 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128931 | — | — | 1 | 7.77 |
| CHEMBL338936 | — | — | 1 | 7.68 |
| CHEMBL128812 | — | — | 1 | 6.75 |
| CHEMBL129144 | — | — | 1 | 6.70 |
| CHEMBL339511 | — | — | 1 | 6.14 |
| CHEMBL338047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128931 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL338936 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL128812 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL129144 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL339511 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL338047 | — | IC50 | = | 0.004 | nM | - |