Assay Detail
Functional
CHEMBL691410
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Tested for the ability to block cleavage of HIV-1 gag polyprotein using [35S]methionine-labeled ligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A bis-[N-3-(1-hydroxy-1-methyl-ethyl)-benzyl)-cyclic urea as a HIV protease inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285417 | — | — | 1 | 8.10 |
| CHEMBL431831 | — | — | 1 | 7.82 |
| CHEMBL21145 | DMP-323 | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285417 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL431831 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL21145 | DMP-323 | IC50 | = | 35.7 | nM | 7.45 |