Assay Detail
Functional
CHEMBL691754
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Concentration required to inhibit HIV replication by 50%
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activity of isonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.25 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.89 |
| CHEMBL421506 | — | — | 1 | 5.09 |
| CHEMBL309913 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL421506 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL309913 | — | IC50 | = | 17500.0 | nM | 4.76 |