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Assay Detail

CHEMBL691761

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration against 50% survival of HIV -1 infected cells relative to uninfected untreated control (in vitro anti HIV-1 activity)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Greco G, Novellino E, Altamura S, Di Renzo L.
J Med Chem (1996) 39 : 2672 -2680
PubMed 8709096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 7 6.10 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL91318 1 6.46
CHEMBL329653 1 6.33
CHEMBL328235 1 6.15
CHEMBL316094 1 6.09
CHEMBL91891 1 6.07
CHEMBL90115 1 5.87
CHEMBL313804 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL91318 EC50 = 350.0 nM 6.46
CHEMBL329653 EC50 = 470.0 nM 6.33
CHEMBL328235 EC50 = 710.0 nM 6.15
CHEMBL316094 EC50 = 810.0 nM 6.09
CHEMBL91891 EC50 = 850.0 nM 6.07
CHEMBL90115 EC50 = 1350.0 nM 5.87
CHEMBL313804 EC50 = 1800.0 nM 5.75