Assay Detail
Binding
CHEMBL691796
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In vitro inhibition of rat liver HMG-CoA reductase
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368185 | — | — | 1 | 9.00 |
| CHEMBL2368197 | — | — | 1 | 9.00 |
| CHEMBL2368189 | — | — | 1 | 9.00 |
| CHEMBL2368202 | — | — | 1 | 8.70 |
| CHEMBL350895 | — | — | 1 | 8.52 |
| CHEMBL2368199 | GLENVASTATIN | 2.0 | 1 | 8.52 |
| CHEMBL2368187 | — | — | 1 | 8.52 |
| CHEMBL2368190 | — | — | 1 | 8.52 |
| CHEMBL2368188 | — | — | 1 | 8.52 |
| CHEMBL2368191 | — | — | 1 | 8.40 |
| CHEMBL2368200 | — | — | 1 | 8.40 |
| CHEMBL2368205 | — | — | 1 | 8.30 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 8.10 |
| CHEMBL2368204 | — | — | 1 | 8.10 |
| CHEMBL2368198 | — | — | 1 | 8.05 |
| CHEMBL2368194 | — | — | 1 | 7.89 |
| CHEMBL2368192 | — | — | 1 | 7.75 |
| CHEMBL156695 | — | — | 1 | 7.72 |
| CHEMBL2368201 | — | — | 1 | 7.52 |
| CHEMBL2368193 | — | — | 1 | 7.44 |
| CHEMBL2111268 | — | — | 1 | 7.42 |
| CHEMBL2368195 | — | — | 1 | 7.40 |
| CHEMBL2368196 | — | — | 1 | 7.03 |
| CHEMBL2111238 | — | — | 1 | 7.00 |
| CHEMBL2111271 | — | — | 1 | 6.58 |
| CHEMBL2368203 | — | — | 1 | 6.30 |
| CHEMBL2111270 | — | — | 1 | 6.22 |
| CHEMBL158323 | — | — | 1 | 6.00 |
| CHEMBL2111237 | — | — | 1 | - |
| CHEMBL2111239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368185 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2368197 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2368189 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2368202 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL350895 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2368199 | GLENVASTATIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2368187 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2368190 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2368188 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2368191 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2368200 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2368205 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2368204 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2368198 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2368194 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2368192 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL156695 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2368201 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2368193 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2111268 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2368195 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2368196 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2111238 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2111271 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2368203 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2111270 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL158323 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2111237 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2111239 | — | IC50 | > | 1000.0 | nM | - |