Compound Detail
CHEMBL2368199
GLENVASTATIN 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
CC(C)c1nc(-c2ccccc2)cc(-c2ccc(F)cc2)c1/C=C/[C@@H]1C[C@@H](O)CC(=O)O1
Basic Information
| ChEMBL ID | CHEMBL2368199 |
| Name | GLENVASTATIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LJIZUXQINHXGAO-ITWZMISCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
5
Known Names
Molecular Properties
431.5
MW (Da)
5.76
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.52
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL3247 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL402 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | IC50 | = | 3.0 | nM | 8.52 | In vitro inhibition of rat liver HMG-CoA reductase | 2296036 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | IC50 | = | 5.0 | nM | 8.3 | Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, dete... | 2296036 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2296036 | 10.1021/jm00163a010 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 3 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
Data from ChEMBL 36 via Core Engine