Assay Detail
Functional
CHEMBL691883
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The compound was tested for inhibitory activity against E-Selectin mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.37 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6248 | — | — | 1 | 6.16 |
| CHEMBL404794 | — | — | 1 | 5.85 |
| CHEMBL336269 | — | — | 1 | 5.48 |
| CHEMBL143702 | — | — | 1 | 5.18 |
| CHEMBL344685 | — | — | 1 | 5.10 |
| CHEMBL345936 | — | — | 1 | 5.10 |
| CHEMBL139936 | — | — | 1 | 5.07 |
| CHEMBL140503 | — | — | 1 | 5.04 |
| CHEMBL143866 | — | — | 1 | - |
| CHEMBL359041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6248 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL404794 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL336269 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL143702 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL344685 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL345936 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL139936 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL140503 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL143866 | — | IC50 | < | 4000.0 | nM | - |
| CHEMBL359041 | — | IC50 | < | 4000.0 | nM | - |