Assay Detail
Functional
CHEMBL691889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition HCV NS5B-mediated RNA synthesis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.25 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | — | 1 | 6.89 |
| CHEMBL73502 | — | — | 1 | 6.22 |
| CHEMBL308370 | — | — | 1 | 5.80 |
| CHEMBL420751 | — | — | 1 | 5.75 |
| CHEMBL73809 | — | — | 1 | 5.72 |
| CHEMBL305890 | — | — | 1 | 5.58 |
| CHEMBL76105 | — | — | 1 | 5.40 |
| CHEMBL2021379 | — | — | 1 | 4.70 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 4.66 |
| CHEMBL72928 | — | — | 1 | 4.55 |
| CHEMBL306299 | — | — | 1 | 4.34 |
| CHEMBL73237 | — | — | 1 | 4.33 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 4.30 |
| CHEMBL307872 | — | — | 1 | - |
| CHEMBL2311161 | — | — | 1 | - |
| CHEMBL75667 | — | — | 1 | - |
| CHEMBL480143 | — | — | 1 | - |
| CHEMBL309579 | 2'-BETA-FLUORO-2',3'-DEOXYADENOSINE | — | 1 | - |
| CHEMBL311635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL73502 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL308370 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL420751 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL73809 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL305890 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL76105 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2021379 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL305686 | CORDYCEPIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL72928 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL306299 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL73237 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1090 | VIDARABINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL307872 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2311161 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL75667 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL480143 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL309579 | 2'-BETA-FLUORO-2',3'-DEOXYADENOSINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL311635 | — | IC50 | > | 50000.0 | nM | - |