Compound Detail
CHEMBL73237
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL73237 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FPUGCISOLXNPPC-IOSLPCCCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
281.3
MW (Da)
-1.33
ALogP
9
HBA
3
HBD
128.5
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A3 CHEMBL256 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| RNA-directed RNA polymerase CHEMBL4296320 | IC50 | 4.33 | 4.33 | 47000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A3 | IC50 | = | 15.0 | nM | 7.82 | Antagonist activity at human adenosine A3 receptor after 15 to 30 mins | 17560111 |
| RNA-directed RNA polymerase | IC50 | = | 47000.0 | nM | 4.33 | Inhibition HCV NS5B-mediated RNA synthesis | 15084127 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17560111 | 10.1016/j.bmc.2007.05.056 | Adenosine receptor A3 | 3 |
| 15084127 | 10.1021/jm030424e | RNA-directed RNA polymerase | 2 |
| 17560111 | 10.1016/j.bmc.2007.05.056 | Adenosine receptor A1 | 2 |
| 7707320 | 10.1021/jm00007a014 | Adenosine receptor A1 | 1 |
| 7707320 | 10.1021/jm00007a014 | Adenosine receptor A2a | 1 |
| 7707320 | 10.1021/jm00007a014 | Adenosine receptor A3 | 1 |
Data from ChEMBL 36 via Core Engine