Assay Detail
Functional
CHEMBL691955
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Anti-proliferative activity against human tumor cell line HT1080
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Trifluoromethyl ketones as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.02 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113537 | — | — | 1 | 5.66 |
| CHEMBL116702 | — | — | 1 | 5.38 |
| CHEMBL323647 | — | — | 1 | 5.16 |
| CHEMBL331158 | — | — | 1 | 4.92 |
| CHEMBL326529 | — | — | 1 | 4.89 |
| CHEMBL115011 | — | — | 1 | 4.80 |
| CHEMBL112148 | — | — | 1 | 4.70 |
| CHEMBL116578 | — | — | 1 | 4.68 |
| CHEMBL117610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113537 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL116702 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL323647 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL331158 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL326529 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL115011 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL112148 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL116578 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL117610 | — | IC50 | > | 50000.0 | nM | - |