Assay Detail
Functional
CHEMBL691957
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Antiproliferative activity against HT1080 (human fibrosarcoma) cell line.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.21 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57792 | — | — | 1 | 6.92 |
| CHEMBL59316 | — | — | 1 | 6.75 |
| CHEMBL294447 | — | — | 1 | 6.70 |
| CHEMBL294194 | — | — | 1 | 6.58 |
| CHEMBL56214 | — | — | 1 | 6.47 |
| CHEMBL56344 | — | — | 1 | 6.42 |
| CHEMBL58487 | — | — | 1 | 6.32 |
| CHEMBL301223 | — | — | 1 | 6.32 |
| CHEMBL56699 | — | — | 1 | 6.31 |
| CHEMBL59317 | — | — | 1 | 6.15 |
| CHEMBL293812 | — | — | 1 | 6.14 |
| CHEMBL56012 | — | — | 1 | 6.12 |
| CHEMBL55611 | — | — | 1 | 6.11 |
| CHEMBL53363 | — | — | 1 | 6.08 |
| CHEMBL54172 | — | — | 1 | 6.05 |
| CHEMBL54408 | — | — | 1 | 6.00 |
| CHEMBL55719 | — | — | 1 | 5.82 |
| CHEMBL56782 | — | — | 1 | 5.72 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL54409 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57792 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL59316 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL294447 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL294194 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL56214 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL56344 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL58487 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL301223 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL56699 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL59317 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL293812 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL56012 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL55611 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL53363 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL54172 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL54408 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL55719 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL56782 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL54409 | — | IC50 | = | 2500.0 | nM | 5.60 |