Assay Detail
Functional
CHEMBL692142
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Inhibition of HDJ2 farnesylation in PSN-1 cells over 7 hr assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PSN-1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.27 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312137 | — | — | 1 | 8.33 |
| CHEMBL502560 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312137 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL502560 | — | EC50 | = | 6.1 | nM | 8.21 |