Compound Detail
CHEMBL502560
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Basic Information
| ChEMBL ID | CHEMBL502560 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCMOPVSFMUOUFR-OAQYLSRUSA-N |
4
Targets
7
Activities
2
Assay Types
3
PK Parameters
6
Publications
0
Known Names
Molecular Properties
399.4
MW (Da)
2.80
ALogP
6
HBA
1
HBD
83.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.18
EC50 2 meas. best 8.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095197 | IC50 | 9.18 | 9.18 | 0.7 | 1 |
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.7 | 8.58 | 2.0 | 2 |
| Protein farnesyltransferase CHEMBL2094108 | EC50 | 8.21 | 8.05 | 6.1 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.33 | 5.33 | 4700.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 5.05 | 5.05 | 8900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 9.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| F | 47.0 | % | Canis lupus familiaris |
| T1/2 | 0.78 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 0.66 | nM | 9.18 | Inhibition of Farnesyltransferase in cells, evaluated in a radiotracer assay for... | 12036349 |
| Protein farnesyltransferase | IC50 | = | 2.0 | nM | 8.7 | Inhibition of Farnesyltransferase in PSN-1 cells at 10 pM | 12036349 |
| Protein farnesyltransferase | IC50 | = | 3.5 | nM | 8.46 | Inhibition of human farnesyltransferase in PSN-1 cells. | 12036349 |
| Protein farnesyltransferase | EC50 | = | 6.1 | nM | 8.21 | Inhibition of HDJ2 farnesylation in PSN-1 cells over 7 hr assay | 12036349 |
| Protein farnesyltransferase | EC50 | = | 13.0 | nM | 7.89 | Inhibition of HDJ2 farnesylation in PSN-1 cells over 7 hr assay in the presence ... | 12036349 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 4700.0 | nM | 5.33 | Inhibition of human ERG channel | 19534531 |
| Cytochrome P450 3A4 | IC50 | = | 8900.0 | nM | 5.05 | Inhibition of human Cytochrome P450 3A4 by macrocycles | 12036349 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12036349 | 10.1021/jm010531d | Protein farnesyltransferase | 5 |
| 12036349 | 10.1021/jm010531d | Canis familiaris | 4 |
| 12036349 | 10.1021/jm010531d | Cytochrome P450 3A4 | 2 |
| 12036349 | 10.1021/jm010531d | Geranylgeranyl transferase type I | 1 |
| 12036349 | 10.1021/jm010531d | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 19534531 | 10.1021/jm900002x | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine