Assay Detail

CHEMBL692286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Glucocorticoid receptor (CHEMBL2034) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Glucocorticoid receptor (CHEMBL2034) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Glucocorticoid receptor

CHEMBL2034

Anchored from Assay target.

Protein identity Glucocorticoid receptor

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HepG2
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Glucocorticoid receptor (CHEMBL2034) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.

Kym PR, Kort ME, Coghlan MJ, Moore JL, Tang R, Ratajczyk JD, Larson DP, Elmore SW, Pratt JK, Stashko MA, Falls HD, Lin CW, Nakane M, Miller L, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Nguyen P, Lane BC.
J Med Chem (2003) 46 : 1016 -1030
PubMed 12620078 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.68	8.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL131	PREDNISOLONE	4.0	1	8.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL131	PREDNISOLONE	EC50	=	2.1	nM	8.68