Assay Detail

CHEMBL692434

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Functional

The activity against mutant HIV molecular clone V82A was determined

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease

Kempf DJ, Molla A, Marsh KC, Park C, Rodrigues A, Korneyeva M, Vasavanonda S, McDonald E, Flentge CA, Muchmore S, Wideburg NE, Saldivar A, Cooper A, Kati WM, Stewart KD, Norbeck DW
Bioorg Med Chem Lett (1997) 7 : 699 -704
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.28	9.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL163	RITONAVIR	4.0	1	9.64
CHEMBL159496	—	—	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL163	RITONAVIR	EC50	=	0.23	nM	9.64
CHEMBL159496	—	EC50	=	121.0	nM	6.92