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Assay Detail

CHEMBL692571

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Binding
Binding affinity at human cloned Histamine H3 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histamine H3 receptor (CHEMBL264)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Faghih R, Dwight W, Vasudevan A, Dinges J, Conner SE, Esbenshade TA, Bennani YL, Hancock AA.
Bioorg Med Chem Lett (2002) 12 : 3077 -3079
PubMed 12372505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 7.77 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105762 1 9.17
CHEMBL322873 1 8.77
CHEMBL105515 1 8.67
CHEMBL319000 1 8.56
CHEMBL2112461 1 8.39
CHEMBL102984 1 8.15
CHEMBL105967 1 8.08
CHEMBL106545 1 8.07
CHEMBL323562 1 7.86
CHEMBL421026 1 7.82
CHEMBL106596 1 7.52
CHEMBL106483 1 7.44
CHEMBL105594 1 6.93
CHEMBL102416 1 6.91
CHEMBL320178 1 6.00
CHEMBL101692 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105762 Ki = 0.6761 nM 9.17
CHEMBL322873 Ki = 1.698 nM 8.77
CHEMBL105515 Ki = 2.138 nM 8.67
CHEMBL319000 Ki = 2.754 nM 8.56
CHEMBL2112461 Ki = 4.074 nM 8.39
CHEMBL102984 Ki = 7.079 nM 8.15
CHEMBL105967 Ki = 8.318 nM 8.08
CHEMBL106545 Ki = 8.511 nM 8.07
CHEMBL323562 Ki = 13.8 nM 7.86
CHEMBL421026 Ki = 15.14 nM 7.82
CHEMBL106596 Ki = 30.2 nM 7.52
CHEMBL106483 Ki = 36.31 nM 7.44
CHEMBL105594 Ki = 117.49 nM 6.93
CHEMBL102416 Ki = 123.03 nM 6.91
CHEMBL320178 Ki = 1000.0 nM 6.00
CHEMBL101692 Ki = 1000.0 nM 6.00