Assay Detail
Binding
CHEMBL692572
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Binding affinity for human recombinant H3 receptor
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.22 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27979 | A-349,821 | — | 1 | 9.31 |
| CHEMBL24863 | — | — | 1 | 9.22 |
| CHEMBL27501 | — | — | 1 | 9.16 |
| CHEMBL283313 | — | — | 1 | 9.11 |
| CHEMBL280590 | — | — | 1 | 9.11 |
| CHEMBL25519 | — | — | 1 | 9.07 |
| CHEMBL27933 | — | — | 1 | 9.01 |
| CHEMBL26880 | — | — | 1 | 8.95 |
| CHEMBL25342 | — | — | 1 | 8.68 |
| CHEMBL279463 | — | — | 1 | 8.67 |
| CHEMBL278462 | CIPRALISANT | 2.0 | 1 | 8.67 |
| CHEMBL27697 | — | — | 1 | 8.62 |
| CHEMBL2113223 | — | — | 1 | 8.54 |
| CHEMBL27665 | — | — | 1 | 8.52 |
| CHEMBL25685 | — | — | 1 | 8.46 |
| CHEMBL27444 | — | — | 1 | 8.44 |
| CHEMBL433031 | — | — | 1 | 8.43 |
| CHEMBL2113224 | — | — | 1 | 8.41 |
| CHEMBL436340 | — | — | 1 | 8.36 |
| CHEMBL25205 | — | — | 1 | 8.33 |
| CHEMBL281640 | — | — | 1 | 8.32 |
| CHEMBL282903 | — | — | 1 | 8.29 |
| CHEMBL2113222 | — | — | 1 | 8.26 |
| CHEMBL24468 | — | — | 1 | 8.21 |
| CHEMBL24198 | — | — | 1 | 8.21 |
| CHEMBL27835 | — | — | 1 | 8.19 |
| CHEMBL27339 | — | — | 1 | 8.19 |
| CHEMBL24865 | — | — | 1 | 8.16 |
| CHEMBL280895 | — | — | 1 | 8.16 |
| CHEMBL27209 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27979 | A-349,821 | Ki | = | 0.4898 | nM | 9.31 |
| CHEMBL24863 | — | Ki | = | 0.6026 | nM | 9.22 |
| CHEMBL27501 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL283313 | — | Ki | = | 0.7762 | nM | 9.11 |
| CHEMBL280590 | — | Ki | = | 0.7762 | nM | 9.11 |
| CHEMBL25519 | — | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL27933 | — | Ki | = | 0.9772 | nM | 9.01 |
| CHEMBL26880 | — | Ki | = | 1.122 | nM | 8.95 |
| CHEMBL25342 | — | Ki | = | 2.089 | nM | 8.68 |
| CHEMBL279463 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL278462 | CIPRALISANT | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL27697 | — | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL2113223 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL27665 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL25685 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL27444 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL433031 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL2113224 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL436340 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL25205 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL281640 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL282903 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL2113222 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL24198 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL24468 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL27835 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL27339 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL24865 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL280895 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL27209 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL25688 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL282685 | — | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL282062 | — | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL25501 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL24921 | — | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL27115 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL282016 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL24352 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL24847 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL27545 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL28271 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL24126 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL25126 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL27343 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL281287 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL284320 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL283451 | — | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL25290 | — | Ki | = | 229.09 | nM | 6.64 |