Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL692573

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type C6
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histamine H3 receptor (CHEMBL264)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.
Cowart M, Pratt JK, Stewart AO, Bennani YL, Esbenshade TA, Hancock AA.
Bioorg Med Chem Lett (2004) 14 : 689 -693
PubMed 14741270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 38 8.10 9.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL351231 1 9.35
CHEMBL159087 1 9.26
CHEMBL422893 1 9.15
CHEMBL161781 1 9.02
CHEMBL159519 1 8.92
CHEMBL345588 1 8.72
CHEMBL159617 1 8.65
CHEMBL160113 1 8.65
CHEMBL159565 1 8.64
CHEMBL162591 1 8.62
CHEMBL161130 1 8.52
CHEMBL346562 1 8.46
CHEMBL422360 1 8.40
CHEMBL439645 1 8.37
CHEMBL161796 1 8.29
CHEMBL159476 1 8.25
CHEMBL161534 1 8.23
CHEMBL350639 1 8.23
CHEMBL161101 1 8.23
CHEMBL2112921 1 8.21
CHEMBL350007 1 8.11
CHEMBL161825 1 8.06
CHEMBL161624 1 8.05
CHEMBL161133 1 7.99
CHEMBL159913 1 7.93
CHEMBL161142 1 7.90
CHEMBL158740 1 7.82
CHEMBL159648 1 7.80
CHEMBL159858 1 7.80
CHEMBL158164 1 7.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL351231 Ki = 0.4467 nM 9.35
CHEMBL159087 Ki = 0.5495 nM 9.26
CHEMBL422893 Ki = 0.7079 nM 9.15
CHEMBL161781 Ki = 0.955 nM 9.02
CHEMBL159519 Ki = 1.202 nM 8.92
CHEMBL345588 Ki = 1.905 nM 8.72
CHEMBL159617 Ki = 2.239 nM 8.65
CHEMBL160113 Ki = 2.239 nM 8.65
CHEMBL159565 Ki = 2.291 nM 8.64
CHEMBL162591 Ki = 2.399 nM 8.62
CHEMBL161130 Ki = 3.02 nM 8.52
CHEMBL346562 Ki = 3.467 nM 8.46
CHEMBL422360 Ki = 3.981 nM 8.40
CHEMBL439645 Ki = 4.266 nM 8.37
CHEMBL161796 Ki = 5.129 nM 8.29
CHEMBL159476 Ki = 5.623 nM 8.25
CHEMBL161534 Ki = 5.888 nM 8.23
CHEMBL350639 Ki = 5.888 nM 8.23
CHEMBL161101 Ki = 5.888 nM 8.23
CHEMBL2112921 Ki = 6.166 nM 8.21
CHEMBL350007 Ki = 7.762 nM 8.11
CHEMBL161825 Ki = 8.71 nM 8.06
CHEMBL161624 Ki = 8.913 nM 8.05
CHEMBL161133 Ki = 10.23 nM 7.99
CHEMBL159913 Ki = 11.75 nM 7.93
CHEMBL161142 Ki = 12.59 nM 7.90
CHEMBL158740 Ki = 15.14 nM 7.82
CHEMBL159648 Ki = 15.85 nM 7.80
CHEMBL159858 Ki = 15.85 nM 7.80
CHEMBL158164 Ki = 17.38 nM 7.76
CHEMBL159282 Ki = 17.78 nM 7.75
CHEMBL159343 Ki = 36.31 nM 7.44
CHEMBL161198 Ki = 44.67 nM 7.35
CHEMBL159281 Ki = 48.98 nM 7.31
CHEMBL159463 Ki = 87.1 nM 7.06
CHEMBL436237 Ki = 147.91 nM 6.83
CHEMBL158774 Ki = 316.23 nM 6.50
CHEMBL162536 Ki = 602.56 nM 6.22