Assay Detail
Binding
CHEMBL692575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Histamine H3 receptor competition binding using [3H]Na-methylhistamine
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.84 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 7.47 |
| CHEMBL106931 | — | — | 1 | 6.66 |
| CHEMBL106612 | IMIFURAMINE | — | 1 | 6.64 |
| CHEMBL105803 | — | — | 1 | 6.61 |
| CHEMBL320331 | — | — | 1 | 6.48 |
| CHEMBL109130 | — | — | 1 | 5.99 |
| CHEMBL106913 | — | — | 1 | 5.77 |
| CHEMBL321920 | — | — | 1 | 5.69 |
| CHEMBL321860 | — | — | 1 | 5.66 |
| CHEMBL319658 | — | — | 1 | 5.60 |
| CHEMBL1632410 | — | — | 1 | 5.16 |
| CHEMBL106158 | — | — | 1 | 5.15 |
| CHEMBL108649 | — | — | 1 | 5.09 |
| CHEMBL320279 | — | — | 1 | 4.94 |
| CHEMBL106570 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90 | HISTAMINE | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL106931 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL106612 | IMIFURAMINE | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL105803 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL320331 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL109130 | — | Ki | = | 1023.29 | nM | 5.99 |
| CHEMBL106913 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL321920 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL321860 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL319658 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL1632410 | — | Ki | = | 6918.31 | nM | 5.16 |
| CHEMBL106158 | — | Ki | = | 7079.46 | nM | 5.15 |
| CHEMBL108649 | — | Ki | = | 8128.31 | nM | 5.09 |
| CHEMBL320279 | — | Ki | = | 11481.54 | nM | 4.94 |
| CHEMBL106570 | — | Ki | = | 18620.87 | nM | 4.73 |