Assay Detail
Binding
CHEMBL692576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.57 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 9.32 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 9.07 |
| CHEMBL90019 | IMBUTAMINE | — | 1 | 8.39 |
| CHEMBL78498 | — | — | 1 | 8.35 |
| CHEMBL311473 | — | — | 1 | 8.16 |
| CHEMBL309654 | — | — | 1 | 7.81 |
| CHEMBL78497 | — | — | 1 | 7.48 |
| CHEMBL78838 | — | — | 1 | 7.28 |
| CHEMBL82244 | — | — | 1 | 6.85 |
| CHEMBL81644 | — | — | 1 | 6.23 |
| CHEMBL79126 | — | — | 1 | 5.98 |
| CHEMBL310360 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | Ki | = | 0.4786 | nM | 9.32 |
| CHEMBL82298 | IMMETHRIDINE | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL90019 | IMBUTAMINE | Ki | = | 4.074 | nM | 8.39 |
| CHEMBL78498 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL311473 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL309654 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL78497 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL78838 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL82244 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL81644 | — | Ki | = | 588.84 | nM | 6.23 |
| CHEMBL79126 | — | Ki | = | 1047.13 | nM | 5.98 |
| CHEMBL310360 | — | Ki | = | 1174.9 | nM | 5.93 |