Assay Detail
Binding
CHEMBL692579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for human Histamine H3 receptor by displacing N-[3H]-methylhistamine in SK-N-MC cells was determined
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SK-N-MC |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.48 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129411 | — | — | 1 | 9.29 |
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.24 |
| CHEMBL129306 | — | — | 1 | 9.13 |
| CHEMBL126321 | — | — | 1 | 9.08 |
| CHEMBL339867 | — | — | 1 | 9.06 |
| CHEMBL339324 | — | — | 1 | 9.03 |
| CHEMBL421624 | — | — | 1 | 9.02 |
| CHEMBL340688 | — | — | 1 | 8.91 |
| CHEMBL126829 | — | — | 1 | 8.87 |
| CHEMBL340023 | — | — | 1 | 8.82 |
| CHEMBL129785 | — | — | 1 | 8.77 |
| CHEMBL341491 | — | — | 1 | 8.64 |
| CHEMBL337942 | — | — | 1 | 8.41 |
| CHEMBL129820 | — | — | 1 | 8.08 |
| CHEMBL126904 | — | — | 1 | 8.05 |
| CHEMBL128190 | — | — | 1 | 7.87 |
| CHEMBL129133 | — | — | 1 | 7.30 |
| CHEMBL339215 | — | — | 1 | 7.30 |
| CHEMBL126495 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129411 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL129542 | JNJ-5207852 | Ki | = | 0.5754 | nM | 9.24 |
| CHEMBL129306 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL126321 | — | Ki | = | 0.8318 | nM | 9.08 |
| CHEMBL339867 | — | Ki | = | 0.871 | nM | 9.06 |
| CHEMBL339324 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL421624 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL340688 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL126829 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL340023 | — | Ki | = | 1.514 | nM | 8.82 |
| CHEMBL129785 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL341491 | — | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL337942 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL129820 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL126904 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL128190 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL129133 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL339215 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL126495 | — | Ki | = | 630.96 | nM | 6.20 |