Assay Detail
Functional
CHEMBL692586
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Compound was tested for inhibition of proliferation of HT1080 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Alpha-keto amides as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.52 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113033 | — | — | 1 | 6.92 |
| CHEMBL113034 | — | — | 1 | 6.17 |
| CHEMBL333150 | — | — | 1 | 5.92 |
| CHEMBL324429 | — | — | 1 | 5.57 |
| CHEMBL111898 | — | — | 1 | 5.54 |
| CHEMBL113094 | — | — | 1 | 5.47 |
| CHEMBL112340 | — | — | 1 | 4.89 |
| CHEMBL420300 | — | — | 1 | 4.77 |
| CHEMBL322710 | — | — | 1 | 4.46 |
| CHEMBL112984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113033 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL113034 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL333150 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL324429 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL111898 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL113094 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL112340 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL420300 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL322710 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL112984 | — | IC50 | > | 50000.0 | nM | - |