Assay Detail
Functional
CHEMBL692654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.10 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 5.57 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.36 |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | 4.37 |
| CHEMBL3142953 | — | — | 1 | - |
| CHEMBL3142947 | — | — | 1 | - |
| CHEMBL610413 | — | — | 1 | - |
| CHEMBL611888 | — | — | 1 | - |
| CHEMBL3142948 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL318153 | EDOXUDINE | EC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL3142953 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL3142947 | — | EC50 | = | 210000.0 | nM | - |
| CHEMBL610413 | — | EC50 | > | 256000.0 | nM | - |
| CHEMBL611888 | — | EC50 | > | 228000.0 | nM | - |
| CHEMBL3142948 | — | EC50 | > | 322000.0 | nM | - |