Assay Detail
Functional
CHEMBL692777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological properties of thiophene ring analogues of mianserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544428 | MIANSERIN HYDROCHLORIDE | -1.0 | 1 | 5.42 |
| CHEMBL13644 | — | — | 1 | 5.14 |
| CHEMBL13645 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544428 | MIANSERIN HYDROCHLORIDE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL13644 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL13645 | — | IC50 | = | 19000.0 | nM | 4.72 |