Assay Detail
Functional
CHEMBL692842
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Histamine H2-receptor activity on isolated spontaneously beating guinea pig atrium
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 4.63 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112753 | — | — | 1 | 4.80 |
| CHEMBL326624 | — | — | 1 | 4.70 |
| CHEMBL115091 | — | — | 1 | 4.40 |
| CHEMBL112099 | — | — | 1 | - |
| CHEMBL113404 | — | — | 1 | - |
| CHEMBL113403 | — | — | 1 | - |
| CHEMBL322481 | — | — | 1 | - |
| CHEMBL112681 | — | — | 1 | - |
| CHEMBL115169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112753 | — | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL326624 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL115091 | — | Kd | = | 39810.72 | nM | 4.40 |
| CHEMBL112099 | — | Kd | > | 50118.72 | nM | - |
| CHEMBL113404 | — | Kd | > | 50118.72 | nM | - |
| CHEMBL113403 | — | Kd | > | 50118.72 | nM | - |
| CHEMBL322481 | — | Kd | = | 125892.54 | nM | - |
| CHEMBL112681 | — | Kd | = | 158489.32 | nM | - |
| CHEMBL115169 | — | Kd | > | 50118.72 | nM | - |