Assay Detail
Functional
CHEMBL693011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% growth of HaCaT cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.76 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 6.16 |
| CHEMBL353105 | — | — | 1 | 6.16 |
| CHEMBL353263 | — | — | 1 | 6.16 |
| CHEMBL355238 | — | — | 1 | 6.10 |
| CHEMBL168811 | — | — | 1 | 6.05 |
| CHEMBL353682 | — | — | 1 | 6.00 |
| CHEMBL350175 | — | — | 1 | 6.00 |
| CHEMBL107703 | — | — | 1 | 5.96 |
| CHEMBL167957 | — | — | 1 | 5.96 |
| CHEMBL354020 | — | — | 1 | 5.92 |
| CHEMBL166549 | — | — | 1 | 5.92 |
| CHEMBL354526 | — | — | 1 | 5.92 |
| CHEMBL355182 | — | — | 1 | 5.89 |
| CHEMBL165586 | — | — | 1 | 5.89 |
| CHEMBL351431 | — | — | 1 | 5.89 |
| CHEMBL167127 | — | — | 1 | 5.80 |
| CHEMBL166103 | — | — | 1 | 5.80 |
| CHEMBL168756 | — | — | 1 | 5.80 |
| CHEMBL168690 | — | — | 1 | 5.80 |
| CHEMBL133058 | — | — | 1 | 5.77 |
| CHEMBL422550 | — | — | 1 | 5.77 |
| CHEMBL166952 | — | — | 1 | 5.77 |
| CHEMBL167090 | — | — | 1 | 5.77 |
| CHEMBL354118 | — | — | 1 | 5.75 |
| CHEMBL167527 | — | — | 1 | 5.75 |
| CHEMBL354490 | — | — | 1 | 5.75 |
| CHEMBL167134 | — | — | 1 | 5.72 |
| CHEMBL132990 | — | — | 1 | 5.72 |
| CHEMBL165935 | — | — | 1 | 5.66 |
| CHEMBL439837 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46469 | ANTHRALIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL353105 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL353263 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL355238 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL168811 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL353682 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL350175 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL167957 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL107703 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL166549 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL354526 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL354020 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL355182 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL165586 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL351431 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL167127 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL168690 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL168756 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL166103 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL167090 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL166952 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL133058 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL422550 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL354118 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL167527 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL354490 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL167134 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL132990 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL165935 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL439837 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL130038 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL168564 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL167634 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL446176 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL354478 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL168785 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL130209 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL168930 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL354744 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL352330 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL166850 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL168543 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL166395 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL134069 | — | IC50 | = | 4700.0 | nM | 5.33 |