Assay Detail
Functional
CHEMBL693032
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Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.88 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314995 | — | — | 1 | 9.52 |
| CHEMBL315753 | — | — | 1 | 8.70 |
| CHEMBL420609 | — | — | 1 | 7.70 |
| CHEMBL89010 | — | — | 1 | 7.52 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.40 |
| CHEMBL89363 | — | — | 1 | 7.30 |
| CHEMBL432941 | — | — | 1 | 7.22 |
| CHEMBL328029 | — | — | 1 | 7.16 |
| CHEMBL88771 | — | — | 1 | 7.05 |
| CHEMBL88606 | — | — | 1 | 6.96 |
| CHEMBL91815 | — | — | 1 | 6.75 |
| CHEMBL88483 | — | — | 1 | 6.19 |
| CHEMBL313821 | — | — | 1 | 5.57 |
| CHEMBL431996 | — | — | 1 | 5.35 |
| CHEMBL88462 | — | — | 1 | 4.89 |
| CHEMBL86531 | — | — | 1 | 4.78 |
| CHEMBL313746 | — | — | 1 | - |
| CHEMBL91250 | — | — | 1 | - |
| CHEMBL313500 | — | — | 1 | - |
| CHEMBL419682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314995 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL315753 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL420609 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL89010 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL89363 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL432941 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL328029 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL88771 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL88606 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL91815 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL88483 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL313821 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL431996 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL88462 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL86531 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL313746 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL91250 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL313500 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL419682 | — | IC50 | > | 50000.0 | nM | - |