Compound Detail
CHEMBL88462
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Basic Information
| ChEMBL ID | CHEMBL88462 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFORQVNUDXKNNV-ZHZULCJRSA-N |
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
370.4
MW (Da)
5.06
ALogP
2
HBA
2
HBD
54.1
PSA (Ų)
0.63
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HUVEC CHEMBL613979 | IC50 | 5.85 | 5.01 | 1400.0 | 4 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 4.86 | 4.86 | 13900.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.75 | 4.75 | 17700.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HUVEC | IC50 | = | 1400.0 | nM | 5.85 | Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or N... | 10893303 |
| HUVEC | IC50 | = | 13000.0 | nM | 4.89 | Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or N... | 10893303 |
| Platelet-derived growth factor receptor beta | IC50 | = | 13900.0 | nM | 4.86 | Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta | 10893303 |
| HUVEC | IC50 | = | 14640.0 | nM | 4.83 | Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NI... | 10893303 |
| Fibroblast growth factor receptor 1 | IC50 | = | 17700.0 | nM | 4.75 | Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 | 10893303 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 20000.0 | nM | 4.7 | Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial g... | 10893303 |
| HUVEC | IC50 | = | 34080.0 | nM | 4.47 | Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NI... | 10893303 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10893303 | 10.1021/jm9906116 | HUVEC | 4 |
| 10893303 | 10.1021/jm9906116 | Vascular endothelial growth factor receptor 2 | 1 |
| 10893303 | 10.1021/jm9906116 | Fibroblast growth factor receptor 1 | 1 |
| 10893303 | 10.1021/jm9906116 | Platelet-derived growth factor receptor beta | 1 |
| 10893303 | 10.1021/jm9906116 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 10893303 | 10.1021/jm9906116 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine