Assay Detail
Binding
CHEMBL678670
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Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.04 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89363 | — | — | 1 | 7.52 |
| CHEMBL313821 | — | — | 1 | 7.10 |
| CHEMBL86531 | — | — | 1 | 6.70 |
| CHEMBL88483 | — | — | 1 | 6.66 |
| CHEMBL431996 | — | — | 1 | 6.66 |
| CHEMBL314995 | — | — | 1 | 6.57 |
| CHEMBL315753 | — | — | 1 | 6.57 |
| CHEMBL89010 | — | — | 1 | 6.51 |
| CHEMBL91815 | — | — | 1 | 6.06 |
| CHEMBL420609 | — | — | 1 | 5.97 |
| CHEMBL88771 | — | — | 1 | 5.90 |
| CHEMBL432941 | — | — | 1 | 5.87 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.15 |
| CHEMBL328029 | — | — | 1 | 4.98 |
| CHEMBL88606 | — | — | 1 | 4.88 |
| CHEMBL419682 | — | — | 1 | 4.76 |
| CHEMBL88462 | — | — | 1 | 4.75 |
| CHEMBL91250 | — | — | 1 | - |
| CHEMBL313746 | — | — | 1 | - |
| CHEMBL313500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89363 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL313821 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL86531 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL88483 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL431996 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL314995 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL315753 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL89010 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL91815 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL420609 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL88771 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL432941 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL328029 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL88606 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL419682 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL88462 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL91250 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL313746 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL313500 | — | IC50 | > | 20000.0 | nM | - |