Assay Detail
Binding
CHEMBL764822
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Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314995 | — | — | 1 | 8.40 |
| CHEMBL431996 | — | — | 1 | 7.70 |
| CHEMBL88771 | — | — | 1 | 7.40 |
| CHEMBL315753 | — | — | 1 | 6.62 |
| CHEMBL89363 | — | — | 1 | 6.29 |
| CHEMBL432941 | — | — | 1 | 6.17 |
| CHEMBL313821 | — | — | 1 | 6.06 |
| CHEMBL88606 | — | — | 1 | 6.04 |
| CHEMBL89010 | — | — | 1 | 5.99 |
| CHEMBL91250 | — | — | 1 | 5.46 |
| CHEMBL91815 | — | — | 1 | 5.26 |
| CHEMBL328029 | — | — | 1 | 5.26 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.00 |
| CHEMBL88483 | — | — | 1 | 4.94 |
| CHEMBL88462 | — | — | 1 | 4.86 |
| CHEMBL420609 | — | — | 1 | 4.71 |
| CHEMBL313746 | — | — | 1 | 4.15 |
| CHEMBL313500 | — | — | 1 | 4.03 |
| CHEMBL86531 | — | — | 1 | - |
| CHEMBL419682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314995 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL431996 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL88771 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL315753 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL89363 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL432941 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL313821 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL88606 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL89010 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL91250 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL91815 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL328029 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL88483 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL88462 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL420609 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL313746 | — | IC50 | = | 70600.0 | nM | 4.15 |
| CHEMBL313500 | — | IC50 | = | 94010.0 | nM | 4.03 |
| CHEMBL86531 | — | IC50 | < | 780.0 | nM | - |
| CHEMBL419682 | — | IC50 | > | 100000.0 | nM | - |