Assay Detail
Binding
CHEMBL693105
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Inhibition of [125I]iodoproxyfan binding to human histamine H3 receptor of CHO-K1 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Different antagonist binding properties of human and rat histamine H3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.86 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367117 | — | — | 1 | 8.96 |
| CHEMBL296450 | — | — | 1 | 8.68 |
| CHEMBL14690 | CLOBENPROPIT | — | 1 | 8.62 |
| CHEMBL19173 | PROXYFAN | — | 1 | 8.57 |
| CHEMBL424365 | — | — | 1 | 7.75 |
| CHEMBL368948 | — | — | 1 | 7.72 |
| CHEMBL112951 | — | — | 1 | 7.57 |
| CHEMBL19010 | IODOPROXYFAN | — | 1 | 7.39 |
| CHEMBL124270 | — | — | 1 | 7.38 |
| CHEMBL14638 | CIPROXIFAN | — | 1 | 7.34 |
| CHEMBL369714 | — | — | 1 | 7.33 |
| CHEMBL114129 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367117 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL296450 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL14690 | CLOBENPROPIT | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL19173 | PROXYFAN | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL424365 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL368948 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL112951 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL19010 | IODOPROXYFAN | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL124270 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL14638 | CIPROXIFAN | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL369714 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL114129 | — | Ki | = | 87.0 | nM | 7.06 |