Assay Detail
Binding
CHEMBL693109
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Binding affinity for human histamine H3 receptor
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel human histamine H(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 6.66 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49532 | — | — | 1 | 8.70 |
| CHEMBL112621 | — | — | 1 | 8.70 |
| CHEMBL72022 | — | — | 2 | 8.52 |
| CHEMBL324650 | — | — | 1 | 8.30 |
| CHEMBL112011 | — | — | 1 | 8.22 |
| CHEMBL48982 | — | — | 1 | 8.22 |
| CHEMBL111930 | — | — | 1 | 8.15 |
| CHEMBL113551 | — | — | 1 | 8.00 |
| CHEMBL70944 | — | — | 1 | 7.89 |
| CHEMBL113236 | — | — | 1 | 7.82 |
| CHEMBL110015 | — | — | 1 | 7.77 |
| CHEMBL326718 | — | — | 1 | 7.66 |
| CHEMBL431083 | — | — | 1 | 7.55 |
| CHEMBL306911 | — | — | 1 | 7.37 |
| CHEMBL112912 | — | — | 1 | 7.16 |
| CHEMBL70756 | — | — | 1 | 7.10 |
| CHEMBL114231 | — | — | 1 | 6.52 |
| CHEMBL325465 | — | — | 1 | 6.30 |
| CHEMBL445619 | — | — | 1 | 6.06 |
| CHEMBL421680 | — | — | 1 | 6.00 |
| CHEMBL71248 | — | — | 1 | 5.96 |
| CHEMBL71352 | — | — | 1 | 5.89 |
| CHEMBL70383 | — | — | 1 | 5.82 |
| CHEMBL71693 | — | — | 1 | 5.77 |
| CHEMBL310907 | — | — | 1 | 5.72 |
| CHEMBL113145 | — | — | 1 | 5.70 |
| CHEMBL70313 | — | — | 1 | 5.68 |
| CHEMBL302591 | — | — | 1 | 5.62 |
| CHEMBL308142 | — | — | 1 | 5.57 |
| CHEMBL70946 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49532 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL112621 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL72022 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL72022 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL324650 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL112011 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL48982 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL111930 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL113551 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL70944 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL113236 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL110015 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL326718 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL431083 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL306911 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL112912 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL70756 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL114231 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL325465 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL445619 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL421680 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL71248 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL71352 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL70383 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL71693 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL310907 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL113145 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL70313 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL302591 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL308142 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL70946 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL71530 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL112163 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL70874 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL114470 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL112647 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL70945 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL71476 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL71047 | — | Ki | = | 11000.0 | nM | 4.96 |