Assay Detail
Binding
CHEMBL693111
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Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressing CHO cells
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 6.96 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | — | 1 | 8.62 |
| CHEMBL416053 | — | — | 1 | 8.55 |
| CHEMBL290613 | — | — | 1 | 7.58 |
| CHEMBL38123 | — | — | 1 | 7.57 |
| CHEMBL544243 | — | — | 1 | 7.43 |
| CHEMBL36630 | — | — | 1 | 7.38 |
| CHEMBL14638 | CIPROXIFAN | — | 1 | 7.34 |
| CHEMBL39716 | — | — | 1 | 7.26 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 7.22 |
| CHEMBL284528 | — | — | 1 | 7.18 |
| CHEMBL39603 | — | — | 1 | 7.08 |
| CHEMBL39705 | ACETOPROXIFAN | — | 1 | 7.06 |
| CHEMBL37709 | — | — | 1 | 7.06 |
| CHEMBL36549 | — | — | 1 | 7.06 |
| CHEMBL288431 | — | — | 1 | 7.05 |
| CHEMBL417888 | — | — | 1 | 7.04 |
| CHEMBL544242 | — | — | 1 | 7.04 |
| CHEMBL39956 | — | — | 1 | 7.02 |
| CHEMBL289641 | — | — | 1 | 6.97 |
| CHEMBL285060 | — | — | 1 | 6.94 |
| CHEMBL288125 | — | — | 1 | 6.92 |
| CHEMBL290712 | — | — | 1 | 6.91 |
| CHEMBL39791 | — | — | 1 | 6.91 |
| CHEMBL441780 | — | — | 1 | 6.90 |
| CHEMBL38207 | — | — | 1 | 6.90 |
| CHEMBL35869 | — | — | 1 | 6.89 |
| CHEMBL36590 | — | — | 1 | 6.83 |
| CHEMBL39951 | — | — | 1 | 6.80 |
| CHEMBL39644 | — | — | 1 | 6.79 |
| CHEMBL417156 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL416053 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL290613 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL38123 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL544243 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL36630 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL14638 | CIPROXIFAN | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL39716 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL284528 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL39603 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL37709 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL36549 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL39705 | ACETOPROXIFAN | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL288431 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL417888 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL544242 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL39956 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL289641 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL285060 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL288125 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL290712 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL39791 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL441780 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL38207 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL35869 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL36590 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL39951 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL39644 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL417156 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL39369 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL37737 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL40005 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL39980 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL39846 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL38378 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL34844 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL36548 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL37997 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL289935 | — | Ki | = | 761.0 | nM | 6.12 |
| CHEMBL415878 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL38149 | — | Ki | = | 1130.0 | nM | 5.95 |