Assay Detail
Binding
CHEMBL693215
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Inhibition of hormone sensitive lipase (HSL).
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130098 | — | — | 1 | 7.70 |
| CHEMBL339297 | — | — | 1 | 7.64 |
| CHEMBL133388 | — | — | 1 | 7.52 |
| CHEMBL334395 | — | — | 1 | 7.22 |
| CHEMBL335112 | — | — | 1 | 7.21 |
| CHEMBL337714 | — | — | 1 | 7.00 |
| CHEMBL130478 | — | — | 1 | 7.00 |
| CHEMBL130112 | — | — | 1 | 7.00 |
| CHEMBL130666 | — | — | 1 | 7.00 |
| CHEMBL131536 | — | — | 1 | 6.80 |
| CHEMBL131588 | — | — | 1 | 6.77 |
| CHEMBL106126 | — | — | 1 | 6.77 |
| CHEMBL336398 | — | — | 1 | 6.70 |
| CHEMBL336524 | — | — | 1 | 6.68 |
| CHEMBL131051 | — | — | 1 | 6.60 |
| CHEMBL334971 | — | — | 1 | 6.52 |
| CHEMBL130628 | — | — | 1 | 6.40 |
| CHEMBL133580 | — | — | 1 | 6.40 |
| CHEMBL131320 | — | — | 1 | 6.22 |
| CHEMBL336625 | — | — | 1 | 6.16 |
| CHEMBL336538 | — | — | 1 | 6.05 |
| CHEMBL133897 | — | — | 1 | 5.96 |
| CHEMBL338720 | — | — | 1 | 5.82 |
| CHEMBL335033 | — | — | 1 | 5.70 |
| CHEMBL130645 | — | — | 1 | 5.70 |
| CHEMBL130704 | — | — | 1 | 5.40 |
| CHEMBL134061 | — | — | 1 | 5.05 |
| CHEMBL341437 | — | — | 1 | 5.05 |
| CHEMBL336276 | — | — | 1 | - |
| CHEMBL337486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130098 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL339297 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL133388 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL334395 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL335112 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL337714 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130478 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130112 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130666 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131536 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL131588 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL106126 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL336398 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL336524 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL131051 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL334971 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL130628 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL133580 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL131320 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL336625 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL336538 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL133897 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL338720 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL335033 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL130645 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL130704 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL134061 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL341437 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL336276 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL337486 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL335158 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL339995 | — | IC50 | > | 50000.0 | nM | - |