Assay Detail
Binding
CHEMBL693276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atrium
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 4.77 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14587 | — | — | 1 | 5.30 |
| CHEMBL274041 | — | — | 1 | 5.00 |
| CHEMBL276938 | — | — | 1 | 4.90 |
| CHEMBL14868 | — | — | 1 | 4.70 |
| CHEMBL14484 | — | — | 1 | 4.70 |
| CHEMBL14754 | — | — | 1 | 4.70 |
| CHEMBL14364 | — | — | 1 | 4.70 |
| CHEMBL15056 | — | — | 1 | 4.50 |
| CHEMBL15153 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14587 | — | Kd | = | 5011.87 | nM | 5.30 |
| CHEMBL274041 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL276938 | — | Kd | = | 12589.25 | nM | 4.90 |
| CHEMBL14868 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL14484 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL14754 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL14364 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL15056 | — | Kd | = | 31622.78 | nM | 4.50 |
| CHEMBL15153 | — | Kd | = | 39810.72 | nM | 4.40 |