Assay Detail
Functional
CHEMBL693447
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Inhibitory activity against LPS-stimulated 1L-1beta release by cultured human monocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel cytokine release inhibitors. Part I: Triterpenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 7.40 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 7.25 |
| CHEMBL432519 | TINGENONE | — | 1 | 7.24 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | — | 1 | 7.10 |
| CHEMBL56163 | PRISTIMEROL | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL432519 | TINGENONE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL56163 | PRISTIMEROL | IC50 | = | 260.0 | nM | 6.58 |