Assay Detail
Binding
CHEMBL693458
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In vitro binding affinity against histamine H3 receptor from synaptosomes of rat cerebral cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.60 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19439 | IMETIT | — | 1 | 8.55 |
| CHEMBL2145443 | — | — | 1 | 7.35 |
| CHEMBL2145444 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19439 | IMETIT | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2145443 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2145444 | — | EC50 | = | 128.0 | nM | 6.89 |