Assay Detail
Binding
CHEMBL693566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.42 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159087 | — | — | 1 | 8.80 |
| CHEMBL351231 | — | — | 1 | 8.49 |
| CHEMBL159565 | — | — | 1 | 8.21 |
| CHEMBL161781 | — | — | 1 | 8.19 |
| CHEMBL159519 | — | — | 1 | 8.18 |
| CHEMBL159617 | — | — | 1 | 8.16 |
| CHEMBL345588 | — | — | 1 | 8.16 |
| CHEMBL346562 | — | — | 1 | 8.00 |
| CHEMBL161130 | — | — | 1 | 7.85 |
| CHEMBL158740 | — | — | 1 | 7.80 |
| CHEMBL161101 | — | — | 1 | 7.77 |
| CHEMBL162591 | — | — | 1 | 7.66 |
| CHEMBL350639 | — | — | 1 | 7.58 |
| CHEMBL160113 | — | — | 1 | 7.58 |
| CHEMBL422360 | — | — | 1 | 7.54 |
| CHEMBL159858 | — | — | 1 | 7.48 |
| CHEMBL2112921 | — | — | 1 | 7.46 |
| CHEMBL161796 | — | — | 1 | 7.38 |
| CHEMBL158164 | — | — | 1 | 7.37 |
| CHEMBL350007 | — | — | 1 | 7.36 |
| CHEMBL161534 | — | — | 1 | 7.35 |
| CHEMBL439645 | — | — | 1 | 7.33 |
| CHEMBL161142 | — | — | 1 | 7.31 |
| CHEMBL161133 | — | — | 1 | 7.30 |
| CHEMBL161825 | — | — | 1 | 7.23 |
| CHEMBL159648 | — | — | 1 | 7.20 |
| CHEMBL159913 | — | — | 1 | 7.17 |
| CHEMBL161624 | — | — | 1 | 7.02 |
| CHEMBL159343 | — | — | 1 | 6.96 |
| CHEMBL159281 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159087 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL351231 | — | Ki | = | 3.22 | nM | 8.49 |
| CHEMBL159565 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL161781 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL159519 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL159617 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL345588 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL346562 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL161130 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL158740 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL161101 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL162591 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL350639 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL160113 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL422360 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL159858 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2112921 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL161796 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL158164 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL350007 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL161534 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL439645 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL161142 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL161133 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL161825 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL159648 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL159913 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL161624 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL159343 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL159281 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL159463 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL159282 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL161198 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL436237 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL158774 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL162536 | — | Ki | = | 2200.0 | nM | 5.66 |