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Assay Detail

CHEMBL693581

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Functional
Inhibition of HSV-1 DNA synthesis in virus-infected HeLa cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
Crute JJ, Lehman IR, Gambino J, Yang TF, Medveczky P, Medveczky M, Khan NN, Mulder C, Monroe J, Wright GE.
J Med Chem (1995) 38 : 1820 -1825
PubMed 7752206 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.57 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 5.72
CHEMBL298991 1 5.30
CHEMBL51665 1 4.89
CHEMBL300895 1 4.84
CHEMBL3144422 1 4.64
CHEMBL52943 1 4.35
CHEMBL3144423 1 4.31
CHEMBL53912 1 4.21
CHEMBL50321 1 4.21
CHEMBL51501 1 4.16
CHEMBL53605 1 4.12
CHEMBL300431 1 4.04
CHEMBL51613 1 -
CHEMBL53307 1 -
CHEMBL3144426 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR IC50 = 1900.0 nM 5.72
CHEMBL298991 IC50 = 5000.0 nM 5.30
CHEMBL51665 IC50 = 12900.0 nM 4.89
CHEMBL300895 IC50 = 14400.0 nM 4.84
CHEMBL3144422 IC50 = 23000.0 nM 4.64
CHEMBL52943 IC50 = 45000.0 nM 4.35
CHEMBL3144423 IC50 = 49000.0 nM 4.31
CHEMBL53912 IC50 = 62000.0 nM 4.21
CHEMBL50321 IC50 = 61600.0 nM 4.21
CHEMBL51501 IC50 = 69000.0 nM 4.16
CHEMBL53605 IC50 = 75000.0 nM 4.12
CHEMBL300431 IC50 = 91000.0 nM 4.04
CHEMBL51613 IC50 > 200000.0 nM -
CHEMBL53307 IC50 > 200000.0 nM -
CHEMBL3144426 IC50 = 190000.0 nM -