Assay Detail
Functional
CHEMBL693670
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Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | 1.0 | 1 | 6.92 |
| CHEMBL413063 | — | — | 1 | 5.91 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.65 |
| CHEMBL146350 | — | — | 1 | 5.19 |
| CHEMBL344107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL413063 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL146350 | — | EC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL344107 | — | EC50 | > | 275000.0 | nM | - |