Assay Detail
Functional
CHEMBL693810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.49 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281025 | — | — | 1 | 7.22 |
| CHEMBL27154 | — | — | 1 | 7.05 |
| CHEMBL26950 | — | — | 1 | 7.05 |
| CHEMBL26151 | — | — | 1 | 6.82 |
| CHEMBL26964 | — | — | 1 | 6.77 |
| CHEMBL26596 | — | — | 1 | 6.77 |
| CHEMBL284197 | — | — | 1 | 6.70 |
| CHEMBL282077 | — | — | 1 | 6.70 |
| CHEMBL27941 | — | — | 1 | 6.68 |
| CHEMBL26077 | — | — | 1 | 6.64 |
| CHEMBL26597 | — | — | 1 | 6.60 |
| CHEMBL281666 | — | — | 1 | 6.59 |
| CHEMBL26723 | — | — | 1 | 6.54 |
| CHEMBL25755 | — | — | 1 | 6.52 |
| CHEMBL27365 | — | — | 1 | 6.48 |
| CHEMBL26592 | — | — | 1 | 6.41 |
| CHEMBL280972 | — | — | 1 | 6.35 |
| CHEMBL26091 | — | — | 1 | 5.75 |
| CHEMBL26082 | — | — | 1 | 5.19 |
| CHEMBL27195 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281025 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL27154 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL26950 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL26151 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL26964 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL26596 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL284197 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL282077 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL27941 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL26077 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL26597 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL281666 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL26723 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL25755 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL27365 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL26592 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL280972 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL26091 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL26082 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL27195 | — | IC50 | = | 10000.0 | nM | 5.00 |