Assay Detail
Binding
CHEMBL693830
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Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.61 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25626 | — | — | 1 | 9.59 |
| CHEMBL24835 | — | — | 1 | 8.72 |
| CHEMBL24031 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25626 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL24835 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL24031 | — | IC50 | = | 30.0 | nM | 7.52 |