Compound Detail
CHEMBL25626
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Basic Information
| ChEMBL ID | CHEMBL25626 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TTZNDWMUJXPGIQ-LLVKDONJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
311.8
MW (Da)
2.20
ALogP
4
HBA
0
HBD
28.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | IC50 | 9.59 | 9.59 | 0.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | IC50 | = | 0.26 | nM | 9.59 | Inhibition of [3H]mepyramine binding to the histamine receptor in guinea pig cor... | 1673158 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1673158 | 10.1021/jm00108a012 | Cavia porcellus | 3 |
| 1673158 | 10.1021/jm00108a012 | Histamine H1 receptor | 1 |
Data from ChEMBL 36 via Core Engine