Assay Detail
Binding
CHEMBL693948
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Potency at histamine H3 receptor subtype, was tested on guinea pig right ileum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.35 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38123 | — | — | 1 | 7.80 |
| CHEMBL290613 | — | — | 1 | 7.74 |
| CHEMBL39951 | — | — | 1 | 7.51 |
| CHEMBL544243 | — | — | 1 | 7.51 |
| CHEMBL416053 | — | — | 1 | 7.42 |
| CHEMBL39603 | — | — | 1 | 7.21 |
| CHEMBL39716 | — | — | 1 | 7.07 |
| CHEMBL35869 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38123 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL290613 | — | Kd | = | 18.2 | nM | 7.74 |
| CHEMBL39951 | — | Kd | = | 30.9 | nM | 7.51 |
| CHEMBL544243 | — | Kd | = | 30.9 | nM | 7.51 |
| CHEMBL416053 | — | Kd | = | 38.02 | nM | 7.42 |
| CHEMBL39603 | — | Kd | = | 61.66 | nM | 7.21 |
| CHEMBL39716 | — | Kd | = | 85.11 | nM | 7.07 |
| CHEMBL35869 | — | Kd | = | 288.4 | nM | 6.54 |