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Assay Detail

CHEMBL694131

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Functional
Antiproliferative (inhibition of cell growth) activity against HaCaT cells (human keratinocyte line)
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HaCaT
Confidence 1 — Organism
Curated By Expert

Target

HaCaT (CHEMBL614392) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.
Müller K, Prinz H, Gawlik I, Ziereis K, Huang HS.
J Med Chem (1997) 40 : 3773 -3780
PubMed 9371243 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 5.81 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL121770 — — 1 6.30
CHEMBL338978 — — 1 6.30
CHEMBL332779 — — 1 6.22
CHEMBL46469 ANTHRALIN 2.0 1 6.22
CHEMBL123271 — — 1 6.16
CHEMBL415019 — — 1 6.16
CHEMBL274056 NAPHTHAZALIN — 1 6.16
CHEMBL123326 — — 1 6.16
CHEMBL125765 — — 1 6.10
CHEMBL43612 JUGLONE — 1 6.10
CHEMBL273643 — — 1 5.96
CHEMBL106514 — — 1 5.85
CHEMBL125388 — — 1 5.82
CHEMBL122196 — — 1 5.82
CHEMBL286494 HYPERICIN 3.0 1 5.77
CHEMBL123787 — — 1 5.72
CHEMBL123692 — — 1 5.72
CHEMBL125821 — — 1 5.68
CHEMBL125175 — — 1 5.68
CHEMBL339332 — — 1 5.58
CHEMBL125592 — — 1 5.51
CHEMBL126057 — — 1 5.48
CHEMBL126090 — — 1 5.43
CHEMBL412821 — — 1 5.42
CHEMBL126056 — — 1 5.38
CHEMBL421625 — — 1 5.37
CHEMBL333452 — — 1 5.37
CHEMBL125427 — — 1 5.36
CHEMBL124951 — — 1 -
CHEMBL125389 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL121770 — IC50 = 500.0 nM 6.30
CHEMBL338978 — IC50 = 500.0 nM 6.30
CHEMBL46469 ANTHRALIN IC50 = 600.0 nM 6.22
CHEMBL332779 — IC50 = 600.0 nM 6.22
CHEMBL123271 — IC50 = 700.0 nM 6.16
CHEMBL415019 — IC50 = 700.0 nM 6.16
CHEMBL274056 NAPHTHAZALIN IC50 = 700.0 nM 6.16
CHEMBL123326 — IC50 = 700.0 nM 6.16
CHEMBL125765 — IC50 = 800.0 nM 6.10
CHEMBL43612 JUGLONE IC50 = 800.0 nM 6.10
CHEMBL273643 — IC50 = 1100.0 nM 5.96
CHEMBL106514 — IC50 = 1400.0 nM 5.85
CHEMBL125388 — IC50 = 1500.0 nM 5.82
CHEMBL122196 — IC50 = 1500.0 nM 5.82
CHEMBL286494 HYPERICIN IC50 = 1700.0 nM 5.77
CHEMBL123787 — IC50 = 1900.0 nM 5.72
CHEMBL123692 — IC50 = 1900.0 nM 5.72
CHEMBL125821 — IC50 = 2100.0 nM 5.68
CHEMBL125175 — IC50 = 2100.0 nM 5.68
CHEMBL339332 — IC50 = 2600.0 nM 5.58
CHEMBL125592 — IC50 = 3100.0 nM 5.51
CHEMBL126057 — IC50 = 3300.0 nM 5.48
CHEMBL126090 — IC50 = 3700.0 nM 5.43
CHEMBL412821 — IC50 = 3800.0 nM 5.42
CHEMBL126056 — IC50 = 4200.0 nM 5.38
CHEMBL421625 — IC50 = 4300.0 nM 5.37
CHEMBL333452 — IC50 = 4300.0 nM 5.37
CHEMBL125427 — IC50 = 4400.0 nM 5.36
CHEMBL421615 — IC50 > 5000.0 nM -
CHEMBL497001 ALOIN IC50 > 5000.0 nM -
CHEMBL125502 — IC50 > 5000.0 nM -
CHEMBL126813 HARUNGANOL B IC50 > 5000.0 nM -
CHEMBL123148 — IC50 > 5000.0 nM -
CHEMBL125254 — IC50 > 5000.0 nM -
CHEMBL124264 — IC50 > 5000.0 nM -
CHEMBL125762 — IC50 > 5000.0 nM -
CHEMBL125822 — IC50 > 5000.0 nM -
CHEMBL122447 — IC50 > 5000.0 nM -
CHEMBL122192 EMODIN ANTHRONE IC50 > 5000.0 nM -
CHEMBL126105 — IC50 > 5000.0 nM -
CHEMBL121693 — IC50 > 5000.0 nM -
CHEMBL123886 — IC50 > 5000.0 nM -
CHEMBL123724 — IC50 > 5000.0 nM -
CHEMBL333179 ANTHRACENE IC50 > 5000.0 nM -
CHEMBL125337 — IC50 > 5000.0 nM -
CHEMBL127993 — IC50 > 5000.0 nM -
CHEMBL125328 — IC50 > 5000.0 nM -
CHEMBL53418 DANTHRON IC50 > 5000.0 nM -
CHEMBL125389 — IC50 > 5000.0 nM -
CHEMBL124951 — IC50 > 5000.0 nM -