Assay Detail
Functional
CHEMBL694201
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Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.31 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335562 | — | — | 1 | 7.96 |
| CHEMBL137327 | — | — | 1 | 7.96 |
| CHEMBL428104 | — | — | 1 | 7.96 |
| CHEMBL137419 | — | — | 1 | 7.96 |
| CHEMBL135432 | — | — | 1 | 7.92 |
| CHEMBL137206 | — | — | 1 | 7.92 |
| CHEMBL342842 | — | — | 1 | 7.48 |
| CHEMBL138437 | — | — | 1 | 7.48 |
| CHEMBL136977 | — | — | 1 | 7.48 |
| CHEMBL137038 | — | — | 1 | 7.48 |
| CHEMBL137728 | — | — | 1 | 7.48 |
| CHEMBL344261 | — | — | 1 | 7.48 |
| CHEMBL137272 | — | — | 1 | 7.43 |
| CHEMBL343366 | — | — | 1 | 7.00 |
| CHEMBL275998 | — | — | 1 | 7.00 |
| CHEMBL137072 | — | — | 1 | 7.00 |
| CHEMBL343160 | — | — | 1 | 7.00 |
| CHEMBL344641 | — | — | 1 | 7.00 |
| CHEMBL137524 | — | — | 1 | 6.52 |
| CHEMBL138645 | — | — | 1 | 6.52 |
| CHEMBL138282 | — | — | 1 | 6.52 |
| CHEMBL343745 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335562 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL137327 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL428104 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL137419 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL135432 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL137206 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL342842 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL138437 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL136977 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL137038 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL137728 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL344261 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL137272 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL343366 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL275998 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL137072 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL343160 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL344641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL137524 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL138645 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL138282 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL343745 | — | IC50 | = | 450.0 | nM | 6.35 |