Assay Detail
Functional
CHEMBL694231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.34 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24171 | BERGAPTEN | 3.0 | 1 | 5.75 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 5.68 |
| CHEMBL94389 | — | — | 1 | 5.64 |
| CHEMBL53569 | ANGELICIN | — | 1 | 5.58 |
| CHEMBL319973 | — | — | 1 | 5.34 |
| CHEMBL96787 | — | — | 1 | 5.05 |
| CHEMBL94433 | — | — | 1 | 4.88 |
| CHEMBL98624 | — | — | 1 | 4.82 |
| CHEMBL93439 | — | — | 1 | - |
| CHEMBL328335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24171 | BERGAPTEN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL94389 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL319973 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL96787 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL94433 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL98624 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL93439 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL328335 | — | IC50 | > | 20000.0 | nM | - |