Assay Detail
Functional
CHEMBL694352
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In vitro cholesterol biosynthesis inhibition in human HepG2 by measuring the extend of cholesterol radiolabeling after incubation with [14C]mevalonate.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.45 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15929 | — | — | 1 | 7.22 |
| CHEMBL16178 | — | — | 1 | 7.16 |
| CHEMBL267332 | — | — | 1 | 6.27 |
| CHEMBL16004 | — | — | 1 | 5.92 |
| CHEMBL16120 | — | — | 1 | 5.68 |
| CHEMBL15811 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15929 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL16178 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL267332 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL16004 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL16120 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL15811 | — | IC50 | > | 100000.0 | nM | - |