Compound Detail
CHEMBL16004
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(OC[Si](C)(C)c2ccc(N=[N+]=[N-])cc2)c1
Basic Information
| ChEMBL ID | CHEMBL16004 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LBHUXDQJLGYWNM-CSKARUKUSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
460.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Squalene monooxygenase CHEMBL3592 | IC50 | 6.28 | 6.28 | 520.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Squalene monooxygenase | IC50 | = | 520.0 | nM | 6.28 | In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring... | - |
| HepG2 | IC50 | = | 1200.0 | nM | 5.92 | In vitro cholesterol biosynthesis inhibition in human HepG2 by measuring the ext... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00175-3 | Squalene monooxygenase | 1 |
| - | 10.1016/S0960-894X(97)00175-3 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine